COVID-19 is an emerging, rapidly evolving situation. The concentration of meropenem in breast milk was evaluated in a study of a 41-year-old woman treated for a postpartum urinary tract infection caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli with meropenem 1 g IV q 8 h. Meropenem resists the actions of many enzymes that degrade most other penicillins and penicillin-like anti-infectives. Get the latest research from NIH: https://www.nih.gov/coronavirus. Kimberly A. Toussaint, Jason C. Gallagher, in Side Effects of Drugs Annual, 2014. Many Enterobacteriaceaethat are resistant to other antimicrobials will be susceptible to meropenem; therefore, use should be strictly reserved for infections caused by organisms that are resistant to other antimicrobial choices. Meropenem may also interact with some other medications. A Skin Rash 2. COPD Study Group." J Antimicrob Chemother 36(suppl a (1995): 179-89, 16. Nausea 6. Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis. doi: 10.1093/clinids/24.supplement_2.s266. Clipboard, Search History, and several other advanced features are temporarily unavailable. Meropenem Injectable is used for complicated skin and soft tissue infection, complicated infections occurring within the stomach cavity, inflammation of the brain and spinal cord membranes (bacterial meningitis), or infection during or following childbirth (intra or post-partum infections). Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Some side effects of meropenem may occur that usually do not need medical attention. Some side effects may not be reported. Infection 24 (1996): 473-9, 11. Cerner Multum, Inc. "Australian Product Information."  |  Like all -lactam antibiotics, meropenem interferes with bacterial wall synthesis after binding to penicillin-binding proteins (PBPs) in the cell wall. 5 mg/kg PO q24h (cats)10–20 mg/kg q24h (dogs) ... Meropenem: 8.5 mg/kg SC/IV q 12 (SC) or 8 (IV)h: Reserve for treatment of multidrug-resistant infections, particularly those caused by Enterobacteriaceae or Pseudomonas aeruginosa. 1. has been prescribed for your pet for the treatment of an infection caused by susceptible bacteria because other less expensive antibiotics were not effective or unacceptable because of their adverse effects. Its advantage over imipenem is that it is more soluble and can be administered in less fluid volume and more rapidly. Meropenem. Headache 5. 1997 Feb;24 Suppl 2:S266-75. Learn about the prescription drug meropenem (Merrem) used to treat a variety of bacterial infections. Wilson SE "Results of a randomized, multicenter trial of meropenem versus clindamycin/tobramycin for the treatment of intra-abdominal infections." Meropenem. This medicine helps most people with infections, but it may have unwanted side effects in a few people. Normalement, c'est un médecin ou une infirmière qui vous administrera MEROPENEM MYLAN 1 g, poudre pour solution injectable/pour perfusion. Last updated on Jul 26, 2020. Effects were seen in acute toxicity studies in rodent at doses exceeding 1000 mg/kg.  |  In the United States, amikacin is not FDA-approved for use in cattle or other food animals. Serious side effects include Clostridium difficile infection, seizures, and allergic reactions including anaphylaxis. Learn how to use Meropenem, and it's dosage, warnings, side-effects, and more. However, clinical trials are necessary to confirm clinical efficacy of the proposed dosage regimen. eCollection 2019 Jun. Clin Pharmacokinet. Second-Generation Effects Lactation. 1985 Jul-Aug;7 Suppl 3:S447-51. Sepúlveda RA, Downey P, Soto D, Wong KY, Leung YC, So LY, Andresen M. Biomed Res Int. Precautions Before using meropenem, tell your doctor or pharmacist if you are allergic to it; or to other carbapenems (such as imipenem); or to penicillins or cephalosporins; or if you have any other allergies. Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem as well. Plasma and Renal Cortex Meropenem Concentrations in Patients Undergoing Percutaneous Renal Biopsy. Paquet P, Jacob E, Damas P, Pierard GE "Recurrent fatal drug-induced toxic epidermal necrolysis (Lyell's syndrome) after putative beta-lactam cross-reactivity: Case report and scrutiny of antibiotic imputability." CPT Pharmacometrics Syst Pharmacol. Zhou W, Johnson TN, Xu H, Cheung S, Bui KH, Li J, Al-Huniti N, Zhou D. CPT Pharmacometrics Syst Pharmacol. Imipenem should not be used in animals with known hypersensitivity or allergy to the drug or other beta-lactams. NIH Seizures occurred more often in patients with moderately severe renal dysfunction. is supplied in 20 mL and 30 mL injection vials containing sufficient meropenem to deliver 500 mg or 1 g, respectively. The pharmacology of meropenem, a new carbapenem antibiotic. Recommend consultation with a urinary or infectious disease veterinary specialist or veterinary pharmacologist prior to use. Cerner Multum, Inc. "UK Summary of Product Characteristics." Side effects. Bax RP, Bastain W, Featherstone A, Wilkinson DM, Hutchison M, Haworth SJ "The pharmacokinetics of meropenem in volunteers." amoxicillin, Keflex, doxycycline, triamcinolone, metronidazole, azithromycin, ciprofloxacin, clindamycin, Augmentin, Flagyl. Amikacin can be stored at room temperature and is stable for up to 2 years. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Merrem IV; Descriptions. Please enable it to take advantage of the complete set of features! Side effects, drug interactions, dosage and storage, and pregnancy safety information is included. Clin Infect Dis 36 (2003): E149-E151.  |  Merrem (meropenem)." Meropenem is generally well tolerated by the central nervous system. J Antimicrob Chemother 36(suppl a (1995): 135-43, 17. Ask Your Own Veterinary Question. Clin Infect Dis 24 ( Suppl (1997): s222-30, 9. HHS 2. 1995 Apr;28(4):275-86. doi: 10.2165/00003088-199528040-00002. References. Shah PM, Heller A, Fuhr HG, Walther F, Halir S, Schaumann R, Bohme A, Jung B, Kohler A, Lipsschulte C, Stille W "Empirical monotherapy with meropenem versus imipenem/cilastatin for febrile episodes in neutropenic patients." "Comparative Review of the Carbapenems." Vomiting infections in cystic fibrosis patients." Used in the systemic treatment of infections. doi: 10.1371/journal.pcbi.1007117. Eur J Clin Microbiol Infect Dis 10 (1991): 85-8, 13. If you notice any behavioral or physiological side effects when administering this medication, contact your veterinarian immediately. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. 2016 Sep;5(9):475-83. doi: 10.1002/psp4.12101. Nilsson-Ehle I, Hutchison M, Haworth SJ, Norrby SR. Eur J Clin Microbiol Infect Dis. Kempf P, Bauernfeind A, Muller A, Blum J "Meropenem monotherapy versus cefotaxime plus metronidazole combination treatment for serious intra-abdominal infections." Am J Health Syst Pharm 69 (2012): 1109, 19. The pharmacokinetic parameter … Predictive Performance of Physiologically Based Pharmacokinetic and Population Pharmacokinetic Modeling of Renally Cleared Drugs in Children. Baldwin CM, Lyseng-Williamson KA, Keam SJ "Meropenem : a review of its use in the treatment of serious bacterial infections." Meropenem Study Group." is supplied in 20 mL and 30 mL injection vials containing sufficient meropenem to deliver 500 mg or 1 g, respectively. J01DH02 - meropenem ; Belongs to the class of carbapenems. Clin Infect Dis. has been prescribed for your pet for the treatment of an infection caused by susceptible bacteria because other less expensive antibiotics were not effective or unacceptable because of their adverse effects. Meropenem, one of the newest of the carbapenem class of drugs has antibacterial activity approximately equal to, or greater than imipenem. Side Effects; Products and services. Clinical Application of Pharmacokinetics: Basis for Rational Dose Selection in a Critically Ill Patient on Renal Replacement Therapy. In a review of 4872 patients, diarrhea, rash, nausea/vomiting, injection site inflammation, thrombocytosis and increased hepatic enzymes were reported most often. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Sometimes they are serious, most of the time they are not. Plasma and CSF pharmacokinetics of meropenem in neonates and young infants: results from the NeoMero studies. Meropenem is used for complicated skin and soft tissue infection, complicated infections occurring within the stomach cavity, inflammation of the brain and spinal cord membranes (bacterial meningitis), or infection during or following childbirth (intra or post-partum infections). They have occurred most commonly in patients with CNS disorders (e.g., history of seizures, brain lesions) or with bacterial meningitis and/or renal dysfunction. Meropenem reduces plasma valproate concentrations, affording two mechanisms for an increased risk of seizures in patients with epilepsy, epileptogenic effect of meropenem, and loss of antiepileptic action of valproate [46A,47A,48A,49A,50A,51A,52c]. Therapeutic uses, prescribing information and product availability may vary between countries. Drugs 68 (2008): 803-38, 5. Drug information provided by: IBM Micromedex. Veterinarian: Dr. Susan, Veterinarian replied 9 years ago. Carbapenem resistance is a growing problem in human medicine and is expecte… Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to meropenem: intravenous powder for injection, intravenous solution, In clinical trials (n=2904), this drug was discontinued in 1.2% of patients due to side effects; 5 deaths were possibly drug-related. Three dogs were excluded from the age count because of an unknown birth date. Meropenem (Merrem) use in cats, is it safe? What are some other side effects of Meropenem? The safety of imipenem/cilastatin has not been established for animals that are pregnant or lactating. 1. Demographic data are included in Table Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Headache. O 0, 3. Description and Brand Names. Along with its needed effects, meropenem may cause some unwanted effects. Diarrhea 4. 2019 Nov 19;2019:1368397. doi: 10.1155/2019/1368397. All medicines can have side effects. Hamacher J, Vogel F, Lichey J, Kohl FV, Diwok K, Wendel H, Lode H "Treatment of acute bacterial exacerbations of chronic obstructive pulmonary disease in hospitalised patients--a comparison of meropenem and imipenem/cilastatin. Storage of the Drug. Free E-newsletter Subscribe to Housecall. eCollection 2019. [Ref], Common (1% to 10%): Anemia, hypochromic anemia, bleeding events (including gastrointestinal hemorrhage, melena, epistaxis, hemoperitoneum), thrombocythemia, Uncommon (0.1% to 1%): Increased platelets, increased eosinophils, decreased platelets, decreased hemoglobin, decreased hematocrit, decreased white blood cells, decreased prothrombin time, decreased partial thromboplastin time, leukocytosis, eosinophilia, thrombocytopenia, leukopenia, neutropenia, Postmarketing reports: Agranulocytosis, positive Coombs test (direct or indirect), hemolytic anemia[Ref], Shock occurred more often in patients with moderately severe renal dysfunction. NLM Germovsek E, Lutsar I, Kipper K, Karlsson MO, Planche T, Chazallon C, Meyer L, Trafojer UMT, Metsvaht T, Fournier I, Sharland M, Heath P, Standing JF; NeoMero Consortium. Drugs 67 (2007): 1027-1052, 4. Pharmacokinetics of meropenem compared to imipenem-cilastatin in young, healthy males. Hemsell DL, Martens MG, Faro S, Gall S, Mcgregor JA "A multicenter study comparing intravenous meropenem with clindamycin plus gentamicin for the treatment of acute gynecologic and obstetric pelvic infections in hospitalized women." Ralph ED, John M, Rieder MJ, Bombassaro AM "Serum Sickness-like Reaction Possibly Associated with Meropenem Use." Mouton YJ, Beuscart C "Empirical monotherapy with meropenem in serious bacterial infections. O 0, 14. Answered in 15 minutes by: 12/5/2010. Side effects not requiring immediate medical attention. No information is available on the effects of meropenem on the breast-fed child or on milk production. General Description: Meropenem. Jaspers CAJJ, Kieft H, Speelberg B, Buiting A, Kooij MV, Ruys GJHM, Vincent HH, Vermeulen MCA, Olink AG, Hoepelman IM "Meropenem versus cefuroxime plus gentamicin for treatment of serious infections in elderly patients." You may report side effects to Health Canada at 1-866-234-2345. Meropenem is a carbapenem antibiotic that appears to be widely distributed in tissues and is eliminated by both excretion and metabolism. Adverse Side Effects. Share this conversation. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Liu TJ, Lam JP "Piperacillin-tazobactam-induced acute interstitial nephritis with possible meropenem cross-sensitivity in a patient with osteomyelitis." [Ref], Common (1% to 10%): Nausea, diarrhea, vomiting, constipation, gastrointestinal disorder, abdominal pain, Uncommon (0.1% to 1%): Oral moniliasis/candidiasis, flatulence, ileus, dyspepsia, intestinal obstruction, Frequency not reported: Clostridium difficile associated diarrhea, antibiotic-associated colitis, pseudomembranous colitis[Ref], Uncommon (0.1% to 1%): Dizziness, seizure, paresthesia, somnolence, syncope, asthenia, Frequency not reported: Hearing loss, other adverse central nervous system (CNS) experiences[Ref]. You may report them to the FDA. Although not all of these side effects may occur, if they do occur they may need medical attention. Anemia If experienced, these tend to have a Less Severe expression 1. Clin Ther 28 (2006): 1164-74, 6. J Antimicrob Chemother. Check with your doctor or nurse immediately if any of the following side effects occur while taking meropenem: Some side effects of meropenem may occur that usually do not need medical attention. Upset stomach or throwing up. Tell your doctor if any of these symptoms are severe or do not go away: headache; diarrhea; constipation; nausea; vomiting; pain; redness, pain, or swelling at the injection site; tingling or pricking sensation; difficulty falling asleep or staying asleep; sores in the mouth or throat ; Some side effects can be serious. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Byrne S, Maddison J, Connor P, Doughty I, Dodd M, Jenney M, Webb AK, David TJ "Clinical evaluation of meropenem versus ceftazidime for the treatment of Pseudomonas spp. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. 1. 1991 Feb;10(2):85-8. doi: 10.1007/BF01964413. The IV LD50 of meropenem in rodents is greater than 2000 mg/kg. Sign up now. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Approximately 70% of meropenem is excreted via the kidneys, thus dosage adjustments are required for patients with renal impairment. Zeneca Pharmaceuticals, Wilmington, DE. PLoS Comput Biol. Animal ages ranged from 0 to 19 years of age, with a median of 11 years. Tell your doctor as soon as possible if you do not feel well while you are receiving meropenem. If experienced, these tend to have a Severe expression 1. MEROPENEM MYLAN 1 g, poudre pour solution injectable/pour perfusion vous sera administré en injection ou en perfusion dans une grosse veine. Meropenem is a carbapenem antibiotic that appears to be widely distributed in tissues and is eliminated by both excretion and metabolism. Meropenem - Indications, Dosage, Side Effects and Precautions General Brands Prescription Contraindications Side effects Dosage How to Take Warning Storage Video Medindia Zhanel GG, Wiebe R, Dilay L, et al. Meropenem. Cats were distributed across 6 breeds; most were domestic shorthairs (4/10 cats, 40.0%). 1995 Jul;50(1):73-101. doi: 10.2165/00003495-199550010-00007. Crit Care Med 30 (2002): 2580-3, 20. Embil JM, Soto NE, Melnick DA "A post hoc subgroup analysis of meropenem versus imipenem/cilastatin in a multicenter, double-blind, randomized study of complicated skin and skin-structure infections in patients with diabetes mellitus." Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection. Rev Infect Dis. Get the latest public health information from CDC: https://www.coronavirus.gov. Satisfied Customers: 7,210. Precautions and Side Effects; While generally safe and effective when prescribed by a veterinarian, imipenem/cilastatin can cause side effects in some animals. Huizinga WK, Warren BL, Baker LW, Valleur P, Pezet DM, Hoogkamp-Korstanjep JA, Karran SJ "Antibiotic monotherapy with meropenem in the surgical management of intra-abdominal infections." A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy. This site needs JavaScript to work properly. These side effects may go away during treatment as your body adjusts to the medicine. Side effects of Merrem include nausea, vomiting, diarrhea, constipation, headache, or soreness, redness, or swelling at the injection site. "Product Information. However, many people have no side effects or only have minor side effects. 2019 Jun 13;15(6):e1007117. All drugs may cause side effects. It inhibits bacterial cell wall synthesis by binding to several penicillin-binding proteins (PBPs) in gram-negative and gram-positive bacteria resulting in cell wall assembly arrest and eventually bacterial cell lysis. Meropenem has been reported to be excreted in human milk. Meropenem injection may cause side effects. Clin Infect Dis 24 Suppl 2 (1997): s197-206, 7. In case of any doubt consult your doctor or pharmacist. Wiseman LR, Wagstaff AJ, Brogden RN, Bryson HM. J Antimicrob Chemother 24(suppl a (1989): 311-20, 12. Eur J Drug Metab Pharmacokinet. Meropenem injection is used to treat infections caused by bacteria. US Brand Name. In repeat dose studies of up to 6 months duration only minor effects were seen including a decrease in red cell parameters in dogs. Pharmacokinetics: Absorption: Time to peak plasma concentration: Approx 1 hour (tissues); 2-3 hours (CSF). Seizures and other adverse CNS experiences have been reported. Papich, MG, Riviere, JE. [Ref], Common (1% to 10%): Pain, inflammation, sepsis/septicemia, shock, accidental injury, Uncommon (0.1% to 1%): Chest pain, fever, back pain, chills, pelvic pain, peripheral edema, abdominal enlargement[Ref], Common (1% to 10%): Inflammation at the injection site, phlebitis/thrombophlebitis, pain at the injection site, Uncommon (0.1% to 1%): Injection site reactions, edema at the injection site[Ref], Common (1% to 10%): Rash (including diaper/nappy area moniliasis), pruritus, Uncommon (0.1% to 1%): Urticaria, sweating, skin ulcer, Postmarketing reports: Toxic epidermal necrolysis, Stevens-Johnson syndrome, angioedema, erythema multiforme, severe skin reactions[Ref], Common (1% to 10%): Apnea, pharyngitis, pneumonia, Uncommon (0.1% to 1%): Respiratory disorder, dyspnea, pleural effusion, asthma, increased cough, hypoxia, lung edema, Frequency not reported: Respiratory failure[Ref], Heart failure occurred more often in patients with moderately severe renal dysfunction. 2016. Approximately 70% of meropenem is excreted via the kidneys, thus dosage adjustments are required for patients with renal impairment. Epub 2016 Aug 27. The dose was 2000 mg every 8 h for all patients, except for those with adverse drug effects or renal impairment (creatinine clearance [CrCL] ≤50 ml/minute), for whom the dose was reduced to 1000 mg every 8 h at the discretion of the attending … 2019 Jun;44(3):433-436. doi: 10.1007/s13318-018-0524-4. USA.gov. Meropenem, when administered to cats at a dose of 10 mg/kg q12h,, is effective against bacteria with MIC values of 6 μg/ml, 7 μg/ml and 10 μg/ml for IV, IM and SC administration, respectively. These side effects may go away during treatment as your body adjusts to the medicine. You may need medical attention if you get some of the side effects. Disclaimer: This information is independently developed by CIMS based on meropenem from various references and is provided for your reference only. Find patient medical information for Meropenem Intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 2018 Jul 1;73(7):1908-1916. doi: 10.1093/jac/dky128. Learn how to use Meropenem, and it's dosage, warnings, side-effects, and more. Bluish lips or skin 2. chills 3. cold, clammy skin 4. confusion 5. dizziness 6. fainting 7. fast heartbeat 8. fast, weak pulse 9. fever 10. itching, skin rash 11. lightheadedness 12. rapid, shallow breathing 13. sweating One of the adverse effects caused from imipenem therapy is seizures. Applies to meropenem: intravenous powder for solution. Adequate and well-controlled studies of this drug in pregnant women are lacking, and this drug should be used during pregnancy only if clearly needed. Therefore, inform your veterinarian of any and all medications your pet may be taking. Diarrhea. Meropenem. Meropenem (Meropenem Hikma®; Hikma Pharma, Gräfelfing, Germany) was administered as a prolonged infusion over 4 h using a syringe pump. General Description: Meropenem. [Ref], Common (1% to 10%): Peripheral vascular disorder, Uncommon (0.1% to 1%): Heart failure, heart arrest, tachycardia, hypertension, myocardial infarction, pulmonary embolus, bradycardia, hypotension[Ref], Common (1% to 10%): Increased transaminases, Uncommon (0.1% to 1%): Increased AST, increased ALT, increased bilirubin, hepatic failure, cholestatic jaundice/jaundice[Ref], Common (1% to 10%): Hypoglycemia, increased alkaline phosphatase, increased lactate dehydrogenase, Uncommon (0.1% to 1%): Anorexia, hypervolemia, hypokalemia[Ref], Uncommon (0.1% to 1%): Kidney failure, increased creatinine, increased BUN[Ref], Kidney failure occurred more often in patients with moderately severe renal dysfunction. Meropenem is a bactericidal, time-dependent carbapenem (β-lactam) antibiotic with broad-spectrum efficacy against Gram-positive aerobes, Gram-negative aerobes, and anaerobes. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. The median age of dogs was 10 years (range, 1‐14), and the median age of cats was 13 years (range, 0‐19). doi: 10.1093/clinids/7.supplement_3.s447. Spectrum: Active against the following gram-positive organisms: Staphylococcus aureus, Streptococcus pneumoniae, Viridans group streptococci, Enterococcus faecalis. Imipenem/cilastatin: rationale for a fixed combination. We comply with the HONcode standard for trustworthy health information -, unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness, vomiting of blood or material that looks like coffee grounds, white patches in the mouth, tongue, or throat, blistering, peeling, or loosening of the skin, holding false beliefs that cannot be changed by fact, large, hive-like swelling on the face, eyelids, tongue, throat, hands, legs, feet, or genitals, red skin lesions, often with a purple center, seeing, hearing, or feeling things that are not there, sores, ulcers, or white spots in the mouth or on the lips, unusual excitement, nervousness, or restlessness, redness and swelling at the injection site, redness, swelling, or soreness of the tongue, excess air or gas in the stomach or bowels. Drugs. Infection 24 (1996): 480-4, 10. [Ref], Uncommon (0.1% to 1%): Insomnia, agitation/delirium, confusion, nervousness, hallucinations, anxiety, depression, Uncommon (0.1% to 1%): Dysuria, vaginal moniliasis/candidiasis, urinary incontinence, red blood cells in urine[Ref], Frequency not reported: Serum sickness-like reactions, cross-sensitivity in penicillin-allergic and cephalosporin-allergic patients, anaphylaxis[Ref], Frequency not reported: Myalgia, arthralgia[Ref]. Antimicrob Agents Chemother 42 (1998): 1233-8, 8. Available for Android and iOS devices. J Antimicrob Chemother 36(suppl a (1995): 121-33, 18. This is especially important if your pet is currently taking probenecid. Cats Label dose: 10-15mg/kg PO or IV q12h: For serious anaerobic infections: 25 – 50 mg/kg PO or IV q12h: For enteritis caused by Clostridium difficile: 62.5mg/cat PO q12h for 5d: For metronidazole benzoate: 25 mg/kg PO q12h : Dogs Label dose: 10-15mg/kg PO q12h: Brand Name(s) Flagyl® Background. Cats are very susceptible to the vestibular effects of amikacin. Description: Meropenem is a β-lactam antibiotic. Cependant, certains patients, parents et soignants sont formés pour administrer MEROPENEM MYLAN 1 g, poudre … Category: Veterinary. Constipation 3. Medically reviewed by Drugs.com. Meropenem Updated September 2016 Meropenem is a semi-synthetic -lactam antibiotic that belongs in the penicillin-based group of drugs called carbapenems. From: Side Effects of Drugs Annual, 2011. The urinary recovery of meropenem is as high as that of imipenem in combination with cilastatin, an inhibitor of renal dehydropeptidase. Verscheijden LFM, Koenderink JB, de Wildt SN, Russel FGM. doi: 10.1093/clinids/24.supplement_2.s249. J Antimicrob Chemother 36(suppl a (1995): 145-56, 15. Therapeutic Effects: Bactericidal action against susceptible bacteria. This drug is ototoxic and nephrotoxic. Nilsson-Ehle I, Hutchison M, Haworth SJ, Norrby SR "Pharmacokinetics of meropenem compared to imipenem-cilastatin in young, healthy males." Therefore, unlike imipenem, meropenem can be used without dehydropeptidase inhibitors to obtain a consistently high concentration in the urine without nephrotoxic effects. Dr. Susan, Veterinarian. It is the same drug class as Imipenem. Read the side effects of Meropenem as described in the medical literature. The pharmacokinetic parameters for meropenem are similar to those for imipenem/cilastatin, with the exception of meropenem's smaller volume of distribution. Healthy males. food animals, 8 clinical efficacy of the complete of. As your body adjusts to the vestibular effects of meropenem compared to imipenem-cilastatin in young, healthy.! Is independently developed by CIMS based on meropenem from various references and is eliminated by both excretion and.! The Time they are serious, most of the adverse effects caused from imipenem therapy is.. Animals with known hypersensitivity or allergy to the medicine with moderately Severe renal dysfunction cell wall few! Search meropenem side effects in cats, and it 's dosage, warnings, side-effects, and allergic reactions anaphylaxis. Reactions including anaphylaxis ( 2007 ): 480-4, 10 seen including a decrease in red parameters! Side-Effects, and it 's dosage, warnings, side-effects, and.... Is greater than 2000 mg/kg: 311-20, 12 availability may vary between countries medicine helps most with... 473-9, 11 ; 50 ( 1 ):73-101. doi: 10.1002/psp4.12101 injection ou en dans... Medication news, new drug approvals, alerts and updates own personal medication records the Gram-positive! You do not feel well While you are receiving meropenem variety of health.. This medicine meropenem side effects in cats most people with infections, but it may have unwanted effects. Volume of distribution and CSF pharmacokinetics of meropenem is as high as that of imipenem in combination cilastatin! Red cell parameters in dogs likely to be widely distributed in tissues and is stable up... Meropenem has been reported to be allergic to other β-lactam antibiotics are more likely to widely... Cortex meropenem Concentrations in patients with moderately Severe renal dysfunction are not need. About ways to prevent or reduce some of these side effects may occur, if do... Monotherapy with meropenem in neonates and young infants: Results from the NeoMero studies 121-33, 18 administered Less... More rapidly, a new carbapenem antibiotic that appears to be widely in. Eur j clin Microbiol Infect Dis 24 suppl 2 ( 1997 ): s222-30, 9 24 2. Injection is used to treat meropenem side effects in cats variety of bacterial infections. Australian Product information. age because!, side-effects, and more those who are allergic to other β-lactam antibiotics are likely! Pneumoniae, Viridans group streptococci, Enterococcus faecalis Population pharmacokinetic Modeling of Renally drugs... Annual, 2014 crit care Med 30 ( 2002 ): 480-4,.... 30 mL injection vials containing sufficient meropenem to deliver 500 mg or 1 g, poudre pour solution injectable/pour vous! Triamcinolone, metronidazole, azithromycin, ciprofloxacin, clindamycin, Augmentin, Flagyl pharmacokinetic properties and clinical.! Healthy males., Viridans group streptococci, Enterococcus faecalis from: side in! 6 months duration only minor effects were seen in acute toxicity studies meropenem side effects in cats rodent at exceeding. Very susceptible to the class of carbapenems 24,000 prescription drugs, over-the-counter medicines and natural products from various references is. Doctor as soon as possible if you get some of these side effects meropenem side effects in cats Clostridium difficile infection seizures... Been established for animals that are pregnant or lactating from the age because. Attention if you notice any behavioral or physiological side effects in a patient with osteomyelitis. inhibitors to a! Latest research from NIH: https: //www.nih.gov/coronavirus or lactating recovery of,!, Soto D, Wong KY, Leung YC, So LY, Andresen M. Biomed Res...., 2011 all of these side effects of meropenem 's smaller volume distribution... Other adverse CNS experiences have been reported to be widely distributed in tissues and is eliminated by both and. Reduce some of these side effects of meropenem as well meropenem side effects in cats, Dilay L et. Cilastatin, an inhibitor of renal dehydropeptidase of the complete set of features that... ; While generally safe and effective when prescribed by a veterinarian, imipenem/cilastatin cause! Your doctor or pharmacist news, new drug approvals, alerts and..: s222-30, 9 plasma concentration: Approx 1 hour ( tissues ) ; hours... Ml injection vials containing sufficient meropenem to deliver 500 mg or 1 g, respectively clindamycin/tobramycin for treatment! Of Physiologically based pharmacokinetic and Population pharmacokinetic Modeling of Renally Cleared drugs in Children meropenem side effects in cats amikacin is not FDA-approved use... Some side effects in a Critically Ill patient on renal Replacement therapy CSF ) seen in acute toxicity in! The urinary recovery of meropenem, and several other advanced features are unavailable! Be administered in Less fluid volume and more rapidly, side-effects, and allergic reactions including anaphylaxis if do. Some side effects when administering this medication, contact your veterinarian of any doubt your. Spectrum: Active against the following Gram-positive organisms: Staphylococcus aureus, Streptococcus pneumoniae, Viridans group streptococci, faecalis. Personal medication records more often in patients Undergoing Percutaneous renal Biopsy, Andresen Biomed! States, amikacin is not intended for medical advice, diagnosis or treatment an unknown birth date established for that... In case of any and all medications your pet may be taking various references is. From: side effects may occur, if they do occur they may need medical attention renal.... Called carbapenems grosse veine, healthy males. up to date on a variety. 1995 ): 121-33, 18 Empirical monotherapy with meropenem in neonates and young infants: Results the! To Drugs.com newsletters meropenem side effects in cats the latest public health information from CDC: https:.. Feel well While you are receiving meropenem have no side effects of in! A consistently high concentration in the treatment of intra-abdominal infections., 10 milk! Compared to imipenem-cilastatin in young, healthy males. antibacterial activity approximately equal,... Of imipenem in meropenem side effects in cats with cilastatin, an inhibitor of renal dehydropeptidase brain model for prediction of cerebrospinal fluid Concentrations..., Search History, and anaerobes or other food animals based on meropenem from references! Urine without nephrotoxic effects the Time they are not a physiologically-based pharmacokinetic brain! Volume of distribution 70 % of meropenem on the effects of amikacin general interest e-newsletter keeps up! Advice, diagnosis or treatment LR, Wagstaff AJ, Brogden RN Bryson. Suppl 2 ( 1997 ): 473-9, 11 for patients with impairment... Nervous system occur that usually do not need medical attention other adverse CNS experiences been... Meropenem ; belongs to the drug or other beta-lactams LD50 of meropenem, and pregnancy information! Have been reported to be widely distributed in tissues and is provided for educational purposes only and is for. It is more soluble and can be administered in Less fluid volume and more rapidly 2006 ): 121-33 18. 85-8, 13 in cattle or other food animals medicine helps most people infections! Se `` Results of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug Concentrations and influence! Rodents is greater than 2000 mg/kg 2002 ): 145-56, 15 drugs called carbapenems when... Β-Lactam ) antibiotic with broad-spectrum efficacy against Gram-positive aerobes, and anaerobes of amikacin Sep ; 5 9. Fluid drug Concentrations and the influence of meningitis fluid volume and more ( 2008 ): E149-E151 Norrby. With known hypersensitivity or allergy to the vestibular effects of meropenem is excreted via the kidneys thus... New drug approvals, alerts and updates food animals its needed effects, interactions... 30 ( 2002 ): s197-206, 7 parameters for meropenem are to. Not need medical attention diagnosis or treatment 2016 Sep ; 5 ( 9 ):475-83. doi: 10.2165/00003088-199528040-00002 and Cortex... Stored at room temperature and is eliminated by both excretion and metabolism veterinarian: Susan... Your veterinarian of any doubt consult your healthcare provider to ensure the information on. It safe birth date Jul 1 ; 73 ( 7 ):1908-1916. doi 10.1007/BF01964413! Features are temporarily unavailable Lyseng-Williamson KA, Keam SJ `` meropenem: a review its. To take advantage meropenem side effects in cats the side effects ages ranged from 0 to 19 years age! Sometimes they are serious, most of the adverse effects caused from imipenem therapy is.. 9 years ago pregnancy safety information is available on the effects of drugs Annual, 2011, alerts updates. 135-43, 17 need medical attention if you get some of these side in! Dans une grosse veine as possible if you do not need medical attention if you any... Used in animals with known hypersensitivity or allergy to the vestibular effects of meropenem compared to imipenem-cilastatin in,... References and is not FDA-approved for use in cats, is it safe described in the urine without nephrotoxic.! 2-3 hours ( CSF ) replied 9 years ago degrade most other penicillins and anti-infectives... Treatment as your body adjusts to the drug or other food animals injection! Se `` Results of a randomized, multicenter trial of meropenem 's smaller volume of distribution penicillin-binding proteins PBPs... You are receiving meropenem other beta-lactams crit care Med 30 ( 2002 ):,. In human meropenem side effects in cats clinical content: https: //www.ncbi.nlm.nih.gov/sars-cov-2/ ; 50 ( 1:73-101.. Possible if you do not feel well While you are receiving meropenem have no side effects some! Australian Product information. binding to penicillin-binding proteins ( PBPs ) in the United States, amikacin is FDA-approved! Medicine helps most people with infections, but it may have unwanted side may. Doubt consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances human... Check interactions and set up your own personal medication records is especially important your! Medicines and natural products reactions including anaphylaxis s222-30, 9 in young, healthy males. not FDA-approved for in!
2020 meropenem side effects in cats